Late lytic antigens also generate a specific CD8+ T-cell response as revealed by comparing T-cell clones from infectious mononucleosis patients with those of long-term carriers.39 In addition to proteins encoded by EBV in the lytic phase, CD8+ T cells respond to latent antigens, especially EBNA-2 and EBNA-3.40, 41 Thus, the T-cell response is directed at both lytic and latent infections in carriers. The gene discussed is CD8A; the disease is infectious mononucleosis.