The expression of Wee1 was in fact higher in CD133+ compared to CD133– primary glioblastoma cells (Mir et al., 2010), and Wee1 was among the most downregulated genes upon differentiation of PTEN positive glioblastoma stem cells (Forte et al., 2013), indicating that high levels of Wee1 may be required to maintain a stemlike state. Here, WEE1 is linked to glioblastoma.