The IGFBP2 promoter has been shown to be hypermethylated, in a subset of tumors, including 8% of small cell lung carcinomas (86), >20% of renal cell carcinomas (91), ~30% squamous cell lung cancers (86), 40% of colorectal cancers (92), >70% lung adenocarcinomas (86), and 75% hepatomas (93). The gene discussed is IGFBP2; the disease is lung adenocarcinoma.