Together these findings suggest that the variation in IGFBP2 expression in tumors may reflect the status of tumor suppressors, oncogenes, and/or use of radiation therapy, therefore, the tumor suppressive/oncogenic potential of IGFBP2 should now be evaluated in the context of each mutation in order to demonstrate whether or not IGFBP2 has a functional role. The gene discussed is IGFBP2; the disease is neoplasm.