Approaches to detect changes in protein or RNA levels of IGFBP2 within tumors have been used to hint at whether IGFBP2 might act in a tumor suppressive or oncogenic manner, however, within a given tumor type the expression of IGFBP2 can vary greatly, so below we examine the mechanisms, which regulate IGFBP2 expression in tumors. The gene discussed is IGFBP2; the disease is neoplasm.