IGFBP2 and cancer: Given the difficulties in accurately associating plasma levels of IGFBP2 with cancer patient prognosis or disease progression, as well as reports demonstrating a lack of concordance between tumor immunohistochemistry (IHC) and serum levels of IGFBP2 (12, 52, 85–87), it may be more meaningful to assess the expression of IGFBP2 within the tumor itself.