Given the difficulties in accurately associating plasma levels of IGFBP2 with cancer patient prognosis or disease progression, as well as reports demonstrating a lack of concordance between tumor immunohistochemistry (IHC) and serum levels of IGFBP2 (12, 52, 85–87), it may be more meaningful to assess the expression of IGFBP2 within the tumor itself. The gene discussed is IGFBP2; the disease is neoplasm.