Tumor diameters, measured as an indicator of tumor growth and development, revealed that 90–120 days old K-rasLA1/+; Msh2−/− mice showed a trend toward increased tumor size (although no statistical linear trend was observed), compared with K-rasLA1/+ mice, indicative of accelerated NSCLC growth (Fig. 1C). The gene discussed is MSH2; the disease is non-small cell lung carcinoma.