G34V/R mutations compromise ZMYND11 binding to the H3.3K36me3 peptide (Wen et al. 2014c); however, a role for ZMYND11 has not been shown to date in any of the pediatric glioblastoma models or in chondroblastoma or giant cell tumors of bone. This evidence concerns the gene ZMYND11 and giant cell tumor.