SETD2 and neoplasm: For example, SETD2 (the only enzyme that performs K36me2 to me3 modification) is mutated in renal carcinoma and breast cancer (Duns et al. 2010; Newbold and Mokbel 2010), and NSD2, which generates K36me2, has been shown to be a tumor suppressor (Kuo et al. 2011).