TP53 and glioma: This enrichment for K27 methylation is associated with gene silencing, and genes in this group include cancer-associated genes such as p16INK4A and CDK6. Genes that were reduced for H3K27me3 marks and were transcriptionally upregulated include the glioma-promoting candidate neural restricted transcription factor OLIG2 (Chan et al. 2013), which may promote collapse of p53 signaling (Mehta et al. 2011).