The expression of RCAS1 by the tumor cells and tumor-associated macrophages might help to create the immunosuppressive microenvironment in patients with parotid gland adenocarcinoma, pharyngeal and laryngeal cancer, ovarian cancer, uterine cancer and other types of malignant neoplasms (Dutsch-Wicherek 2010; Dutsch-Wicherek and Kazmierczak 2013; Dutsch-Wicherek et al. 2010, 2012, 2013; Walentowicz-Sadlecka et al. 2013; Jozwicki et al. 2011; Galazka et al. 2012; Wicherek et al. 2012; Sonoda et al. 1996, 2005, 2006, 2008, 2009; Sonoda 2011). This evidence concerns the gene EBAG9 and cancer.