In many cases involving various types of malignant neoplasms, RCAS1 has been demonstrated to be associated with poor prognosis, the development of lymph node metastases and participation in tumor microenvironment remodeling (Dutsch-Wicherek et al. 2009, 2010, 2012; Sonoda et al. 1996, 2005, 2006, 2008, 2009; Sonoda 2011). This evidence concerns the gene EBAG9 and cancer.