In the present study, we demonstrated the presence of RCAS1 protein immunoreactivity in 65 % of the examined tissue samples of DLBCL of the palatine tonsils and in 25 % of the analyzed stromata in which it occurred in CD68-positive cells, which were identified as macrophages and were dispersed throughout the stroma. This evidence concerns the gene CD68 and diffuse large B-cell lymphoma.