In the current study, the levels of immunoreactivity of CD3, CD25, CD68, CD69, Foxp3 and RCAS1 were determined in palatine tonsil DLBCL and its microenvironment and in the tissues of the reference group, including the epithelium lining of the tonsils and the lymphoid tissue of the palatine tonsils derived from patients with chronic tonsillitis. The gene discussed is CD69; the disease is Recurrent tonsillitis.