MMP13 and metastatic malignant neoplasm in the lymph nodes: Many reports indicate that elevated circulating MMP-13 levels are associated with progression and metastasis of various cancers and specifically correlate with decreased overall patient survival and increased lymph node metastasis in breast cancer44, increased bone metastasis in renal cell carcinoma45, and poor prognosis of non-small cell lung and colorectal cancers46, 47.