CXCR4 and neoplasm: To determine whether attenuated CXCL12-dependent CXCR4 signaling in ANGPTL2 knockdown MB231 cells alters their invasivity, we compared CXCL12-accelerated, collagenolysis-dependent tumor cell invasivity in MB231/miANGPTL2 versus control MB231/miLacZ cells using wound healing assays on type I collagen-coated plates.