For example, a number of changes in total cellular mRNAs have been shown to occur upon latent during experimentally latent infection of granulocyte macrophage progenitors (GMPs) [37, 38] resulting in changes in MHC class II expression and secreted monocyte chemoattractant protein-1 (MCP-1) also known as chemokine C–C motif ligand-2 (CCL2) [39]. This evidence concerns the gene CCL2 and disease arising from reactivation of latent virus.