HMGB1 was found to up-regulate the expression of MMP-9, which belongs to matrix metalloproteinases (MMPs) involved in the initiation, invasion, and metastasis of many kinds of cancers, in glioma and gastric cancer cells [33, 36], which may explain its association with invasion and metastasis of glioma tumor. The gene discussed is MMP9; the disease is central nervous system cancer.