In vivo, Med1, Med14, Med21, and Cdk8 have been shown to be required in hair follicle stem cells, plant meristem, mouse blastocysts, and tumor cells, respectively (Adler et al., 2012; Autran et al., 2002; Nakajima et al., 2013; Tudor et al., 1999). Here, CDK8 is linked to neoplasm.