Since CCK2R is a potential target in several pathologies of the central nervous system (anxiety, panic attacks), of the gut (peptic ulcer disease) and of neuroendocrine cancers, the effects of a series of such ligands on stimulation of phospholipase-C and as well as on recruitment of non-visual arrestins and stimulation of receptor internalisation have been studied (see Fig. 5). This evidence concerns the gene SAG and Anxiety.