Based on previous studies showing that NK cells drive hyperinflammation in candidiasis in immunocompetent mice (Quintin et al., 2014) and that IL-17 promotes fungal survival (Zelante et al., 2012), we speculate that MDSCs in fungal infections could act beneficial for the host by dampening pathogenic hyperinflammatory NK and Th17 responses (Romani et al., 2008; Zelante et al., 2007). The gene discussed is IL17A; the disease is fungal infectious disease.