We have discovered the regulatory roles of the zebrafish ortholog of mammalian TRPM7 in development of exocrine pancreas, and we subsequently identified the expression and functions TRPM7 and TRPM8 in human pancreatic cancer (Yee, 2013; Yee et al., 2012a; Yee et al., 2013; Yee and Yee, 2013; Yee et al., 2010; Yee et al., 2012b; Yee et al., 2011). This evidence concerns the gene TRPM8 and familial pancreatic carcinoma.