In pancreatic intra-epithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasm (IPMN), there is a moderate level of TRPM7 expression that appears to be localized on the plasma membrane (Fig. 1C,D). Here, TRPM7 is linked to pancreatic intraductal papillary-mucinous neoplasm.