Yet, in the liver-draining hepatic lymph nodes of mice with PBC, CD4+ Foxp3+ cells were 23.8 ± 1.2% of CD4+ T cells, compared to only 12.2 ± 0.8% in healthy controls (Fig. 1B; P = 0.0014, non-parametric t test). Here, CD4 is linked to primary biliary cholangitis.