On the other hand, this observation is in agreement with several recent reports showing that JQ1 and the pan-deacetylase inhibitor panobinostat (or tyrosine kinase inhibitors) synergistically induce apoptosis of leukemia cells expressing constitutive active STAT5 but not of normal hematopoietic progenitor cells (42,48,49). Here, STAT5A is linked to leukemia.