Despite the generally low PSI values for the 325 cryptic 3’SSs from the CLL-only analysis, we identified four genes previously implicated in cancer (TTI1 [24–26], MAP3K7 [27–29], FXYD5 [30], PFDN5 [31]) and six others (YIF1A, ORAI2, ZNF91, ZNF548, RP11–1280I22. The gene discussed is ORAI2; the disease is cancer.