ENG and atherosclerosis: Sol-Eng+ mice have high plasma concentrations of human soluble endoglin within the range of 2,000–3,000 ng/mL that are far more elevated when compared to hypercholesterolemic mice with advanced atherosclerosis, where plasma concentrations of mouse soluble endoglin amounted to 2,000–3,000 pg/mL [22], which is almost 1000x less than in mice used in this study.