Finally, secretions were profiled in the conditioned medium of patient-isolated TEM and revealed that tumor TEM are paracrine inducers of tumor angiogenesis by releasing high levels of angiogenic factors (i.e. VEGF, bFGF, and ANG-1) and MMP9 (matrix metalloproteinase 9) (Fig. 1B). Here, FGF2 is linked to neoplasm.