Down-regulation and desensitization of the β2-AR is observed in many diseases where net SNS firing rate (activity) is chronically elevated and robust/chronic inflammation ensues, including hypertension [71], sepsis [72,73,74], rheumatoid arthritis (RA) [75,76,77], and asthma [78,79,80]. The gene discussed is ADRB2; the disease is hypertensive disorder.