In contrast to our findings, previous studies identified the T-allele of rs7216389 in ORMDL3/GSDMB as the childhood asthma risk allele.[34,35,37] Exposure to environmental factors such as tobacco smoke and domestic furry pets, have been demonstrated to modify the relationship between polymorphisms in ORMDL3/GSDMB and childhood asthma.[41,42] Remarkable was the difference in prevalence of parental smoking between the ADEM and the KOALA study even though the same definition for passive smoking was used. The gene discussed is GSDMB; the disease is asthma.