ADAM33 was first reported as a susceptibility gene for asthma and bronchial hyper-responsiveness through genome wide linkage analysis identifying a candidate region on chromosome 20p.[21] ADAM33 consists of 22 exons which can generate a protein with eight different functional domains.[22] The gene is highly polymorphic, containing more than 70 SNPs with extensive LD. The gene discussed is ADAM33; the disease is asthma.