Even when the confounding effects of the APOE e4 allele, hypertension, and diabetes were considered together, the overall results were unchanged (K-BNT: -0.426 [-0.781, -0.071], p = 0.019; SVLT-delayed recall: -0.063 [-0.138, 0.012], p = 0.101; RCFT-copy: -0.041 [-0.569, 0.486], p = 0.877; COWAT: -0.176 [-0.328, -0.023], p = 0.024; Stroop: -0.304 [-0.458, -0.150], p<0.001). This evidence concerns the gene APOE and Hypertension.