Several epidemiologic studies have shown that the co-existence of hypertension and diabetes or obesity is due to common genetic and environmental factors such as diet, physical activity and age.[25] However, in obese girls with high sodium intake, sodium intake may be an independent risk factor of obesity-induced insulin resistance independent of BP, because BP and blood insulin, HOMA-IR, TG and LDL were not increased. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.