AGT and obesity due to melanocortin 4 receptor deficiency: One possible explanation is the inflammatory cytokines such as IL-6 resulting from the excess fat may cause the body to retain more sodium and fluid, and elevate BP by activating ENaC.[9] This gives motive for physicians to prescribe antihypertensive or anti-obesity therapeutic medicine such as statin or angiotensin II antagonists as they are known to inhibit the secretion of inflammatory factors.[35] The second possibility is the increased ability to incorporate glucose into lipids was observed in isolated adipocytes from high sodium diet tested on rats.