One possible explanation is the inflammatory cytokines such as IL-6 resulting from the excess fat may cause the body to retain more sodium and fluid, and elevate BP by activating ENaC.[9] This gives motive for physicians to prescribe antihypertensive or anti-obesity therapeutic medicine such as statin or angiotensin II antagonists as they are known to inhibit the secretion of inflammatory factors.[35] The second possibility is the increased ability to incorporate glucose into lipids was observed in isolated adipocytes from high sodium diet tested on rats. This evidence concerns the gene IL6 and obesity disorder.