Our findings regarding plasma concentration of CTRP1 and T2DM, were in accordance with the recent studies in which serum level of CTRP1 was significantly higher in T2DM, MetS and CAD patients compared to healthy people [15,20,21], however, in contrast to our results, another study demonstrated that circulating level of CTRP1 was significantly decreased in diet-induced obese mice. This evidence concerns the gene C1QTNF1 and type 2 diabetes mellitus.