The IgG titers of these patients are log multiplications higher than singular reactive titers and their corresponding IgM titers, which is highly indicative for secondary and frequent flavivirus infections.[16] Distinguishing primary from secondary or multiple flavivirus infections is serologically difficult.[16] Further investigation into patients with known multiple flavivirus infections will be needed to further define the uses of our multiplex array testing in such patient populations. Here, CD40LG is linked to Flavivirus Infections.