By histological analysis, the lung adenocarcinomas in EGFRTL/CCSP-rtTA/Cebpb-/- mice tended to demonstrate a more central bronchial papillary growth pattern (Fig. 5C; III), whereas the adenocarcinomas in EGFRTL/CCSP-rtTA/Cebpb+/+mice tended to have a more peripheral distribution with solid and bronchioalveolar growth features (Fig. 5C; I). Here, CEBPB is linked to lung adenocarcinoma.