GDF15 and neoplasm: Although this analysis comprised fewer data points, the difference between tumor and disease-free tissues (p(t)<0.01; p(WRS)<0.05), and between tumor adjacent and disease-free tissues (p(t)<0.05; p(WRS)<0.0001) remained significant, while MIC-1 expression in tumor and tumor-adjacent tissues (p(t) = 0.97; p(WRS) = 0.95) was similar (Fig. 2B).