Although the present study was not designed nor powered to conclusively determine the association of MIC-1 and PDGF-A with clinical parameters, we observed that MIC-1 expression levels significantly differentiated pathological stage T2 from T3 in tumor tissues (p<0.001 to p<0.05), and were moderately associated with Gleason scores ≤6 vs. 6 and ≤7 vs. 7 (p<0.05 to 0.13). This evidence concerns the gene GDF15 and neoplasm.