Quantitation by both the WSA and ROI methods (Figs. 3C and 3D) revealed similar MIC-1 expression levels in tumor and tumor-adjacent tissues (0.9x by WSA [p(t) = 0.47; p(WRS) = 0.76] and 1.0x by ROI [p(t) = 0.59; p(WRS) = 0.82]) (Table 2). Here, GDF15 is linked to neoplasm.