10 Aruna Chalam Aruna Chalam G G Samuel Samuel SM SM Marie Marie I I Ding Ding H H Triggle Triggle CR CR Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1 Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1 Br J Pharmacol. Here, SIRT1 is linked to Hyperglycemia.