MLH1 and malignant colon neoplasm: The selective targeting hypothesis for CIMP [31] postulates that certain regions of the genome may have intrinsic features that attract DNA methyltransferases: for example, a common polymorphism in the MLH1 promoter region (−93G > A) was shown to increase the risk of MSI colon cancer with CIMP whereas MSS-CRCs did not show this association [32].