Taken all together, these results suggest that intronic CpG (cg10242476) methylation in TDGF1 transcript variant 2 positively regulates its expression in NB whereas CpG (cg27371741) hypomethylation in the first exon of TDGF1 transcript variant 1 regulates its expression in embryonic stem cells. Here, CRIPTO is linked to neuroblastoma.