MYCN and metastatic neoplasm: Interestingly, the degree of methylation of the proposed biomarkers is able to distinguish between different subgroups of NB: patients who were older than 18 months at diagnosis from younger than 18 months at diagnosis, patients with MYCN-amplified tumors from MYCN non-amplified tumors, patients with metastatic tumors from localized tumors and relapsed or dead patients from relapse-free survivors.