Immunohistochemistry also showed a decreased expression of PD1 in HBV-HCC (+) patients than non-HBVHCC patients (+ + +) (Figure 6); however, there was no significant difference in the expression of PDL1 (ligand for PD1) in HBV-HCC than non-HBVHCC patients. Here, CD274 is linked to hepatocellular carcinoma.