Foxp3 expression in CD4+ CD127low CD25+hi was significantly correlated with both low (<1000, r = 0.857, P = 0.014) and high (>1000, r = 0.914, P = 0.000) AFP values in HBV-HCC patients, which was not correlated in non-HBV-HCC patients (Tables S1–S3 in Supplementary Material). This evidence concerns the gene CD4 and hepatocellular carcinoma.