There was no difference in frequencies of CD8+CD25+ hi in HBV-HCC than non-HBVHCC patients (P = NS, Figures S1A,B in Supplementary Material) but in comparison to CHBV patients, CD8+ Tregs frequencies were slightly higher in HBV-HCC patients (P = 0.05). The gene discussed is CD8A; the disease is hepatocellular carcinoma.