CB1R blockade with rimonabant or genetic reduction of CB1R, normalized cognitive impairment, nociceptive desensitization, susceptibility to audiogenic seizures, overactivated mTOR signaling and altered spine morphology in the male Fmr1 knockout (Fmr1(-/y)) mice, whereas CB2R antagonism with AM630 normalized anxiolytic-like behaviors in those mice (Busquets-Garcia et al., 2013). The gene discussed is CNR1; the disease is Cognitive impairment.