Acute treatment with CTEC corrected the elevated hippocampal LTD, protein synthesis, and audiogenic seizures; chronic treatment rescued cognitive deficits, auditory hypersensitivity, aberrant dendritic spine density, overactive extracellular signal regulated kinase (ERK) and mammalian target of rapamycin (mTOR) signaling, and partially corrected macroorchidism in adult fragile X mice (Michalon et al., 2012). This evidence concerns the gene MTOR and Cognitive impairment.