In Duchenne muscular dystrophy, NFκB activation is perceived as contributing to the deterioration of skeletal muscle pathology and skeletal muscle loss.18 For example, deletion of a single allele of NFkB (RelA/p65 subunit) was sufficient to considerably reduce infiltration of macrophages, fiber necrosis and calcification in dystrophic muscle in mdx mice (DMD mouse model). This evidence concerns the gene NFKB1 and Duchenne muscular dystrophy.