In Duchenne muscular dystrophy, NFκB activation is perceived as contributing to the deterioration of skeletal muscle pathology and skeletal muscle loss.18 For example, deletion of a single allele of NFkB (RelA/p65 subunit) was sufficient to considerably reduce infiltration of macrophages, fiber necrosis and calcification in dystrophic muscle in mdx mice (DMD mouse model). The gene discussed is RELA; the disease is Duchenne muscular dystrophy.