Moreover, higher Cbx4 expression increased the undifferential risk of HCC with an odds ratio (OR) of 1.365 (95% CI 1.008–1.849, P=0.044; Figure 1b), high TNM risk (OR 2.191, 95% CI 1.505–3.190, P=3.3 × 10-5; Figure 1c), HM risk (OR 1.797, 95% CI 1.256–2.573, P=0.001; Figure 1d), and distant metastasis risk (OR 2.349, 95% CI 1.001–5.454, P=0.041; Figure 1e) besides MVD reported previously (OR 11.706, 95% CI 8.170−16.772, P=4.3 × 10−47; Figure 1f). The gene discussed is CBX4; the disease is hepatocellular carcinoma.