SPOP and cancer: The copy number analyzes of amplification, loss of heterozygosity (LOH), and deletion in 24 cancer types revealed LOH at high percentages in the SPOP locus, suggesting genomic loss of the SPOP locus occurs frequently in human cancers.9 Thus, multiple mechanisms such as somatic mutations, LOH, and epigenetic silencing might be utilized by different cancer types to inactivate SPOP.