BCL2 and cancer: Bim functions as a tumor suppressor in various cancers and contains only a protein-interaction motif known as a BH3 domain, allowing it to bind to prosurvival Bcl-2 molecules and neutralize their function.47 In this study, 5a inhibited the phosphorylation of Akt and Erk, leading to dephosphorylation of Bad at Ser112 and Ser136.