Bim functions as a tumor suppressor in various cancers and contains only a protein-interaction motif known as a BH3 domain, allowing it to bind to prosurvival Bcl-2 molecules and neutralize their function.47 In this study, 5a inhibited the phosphorylation of Akt and Erk, leading to dephosphorylation of Bad at Ser112 and Ser136. Here, AKT1 is linked to cancer.