Furthermore, in this study we found a moderate positivity of BAG3 in the islets of Langerhans of pancreatic adenocarcinoma (PDAC) patients, whereas normal pancreatic ducts and pancreatic acinar cells exhibited no BAG3 expression.15 In response to elevated blood-glucose levels, pancreatic-islet β-cells release insulin in order to maintain glucose homeostasis. This evidence concerns the gene BAG3 and pancreatic adenocarcinoma.