LARGE1 and malaria: The estimated Big Dyn-induced pore (2.7 nm) is compatible with the diameter of malaria parasite's nutrient channel (2.3 nm),53 and the diameter of recombinant large-conductance mechanosensitive ion channel (4.0 nm) from Escherichia coli; the latter is the largest ion channel described so far.54 Not surprisingly, these pores are capable of conducting large organic ions such as HEPES− and NMDG+ (approx. molecular radius 0.4 nm).