PAK1 and invasive carcinoma: Mounting evidence has confirmed that PAK1 signaling pathway has a central role in cancer cell migration and invasion.22, 23, 34 Overexpression of PAK1 has been correlated with human cancer invasiveness and tumor grade.21, 26 Importantly, in this study, we found that relative protein expression of RUFY3 was high in clinical gastric cancer samples with invasive carcinoma at pathologic TNM III and TNM IV stages compared with their matched non-tumor adjacent tissues.