The PAKs, a family of serine/threonine protein kinases, have pivotal roles in cytoskeletal reorganization,19 survival,20 motility21, 22 and tumorigenesis.23 There has been mounting evidence that PAK1 is tightly related to the progression and metastasis of cancer and may become a promising diagnostic and therapeutic target for cancer.24, 25 For example, elevated PAK1 expression is correlated with cancer progression and lymph node metastases in gastric cancer tissues.26, 27 Therefore, it is worthwhile to study the novel binding partners of PAK1. The gene discussed is PAK1; the disease is cancer.