RUFY3 and gastric cancer: 1 and 2) targeting RUFY3, and found that the inhibitory effect of cell migration (Supplementary Figure S4e) and invasion (Figure 5d, upper panel) is significantly enhanced by knockdown of both PAK1 and RUFY3, which were also shown in BGC-823 cells (Figure 5d, down panel), suggesting that blocking the expression of PAK1 and RUFY3 can significantly inhibit gastric cancer cell migration and invasion.