PAK1 and gastric cancer: Remarkably, at the 24 h, the effect of promoting SGC-790 cell invasion induced by RUFY3 can be more significantly facilitated by overexpressing PAK1 compared with cells expressing RUFY3 alone (Figure 5a, left panel), and the relative number of invading cells was significantly increased (Figure 5a, right panel), indicating that PAK1 as an important role in RUFY3-mediated facilitating gastric cancer cell migration and invasion.