KLF17 and neoplasm: To investigate the mechanisms involved in HCC metastasis and recurrence might be helpful in the development of novel chemotherapeutic targets.2, 3 Studies have shown that crosstalk and co-operation among different signaling, tumor-suppressor and oncogenic proteins play a crucial role in the epithelial–mesenchymal transition (EMT) and metastasis of cancer.3 Among these molecules and signaling Kruppel-like-factor 17 (KLF17) has been shown to have a critical impact on metastasis and cancer progression.