Moreover, we performed computational analysis to understand the correlation between KLF17 and Smad3 expressions in lung cancer data sets and found that these two tumor-suppressor proteins had strong positive correlation with each other in lung cancers (Figure 8d and Supplementary Figure 6), consistent with the molecular basis of regulatory features in KLF17 and Smad3 identified above. Here, SMAD3 is linked to neoplasm.