Mitofusin 1 (Mfn1), Mfn2 and optic atrophy 1 (OPA1) promote mitochondrial fusion and inhibit apoptosis.28, 29 Drp1, fission 1 (Fis1) and mitochondrial fission factor (Mff) induce mitochondrial fission and apoptosis.30, 31, 32 Accumulating evidence show that abnormality in mitochondrial dynamics can provoke the occurrence of heart disease.26 Our previous studies have demonstrated that mitochondrial dynamic regulators such as Drp1, Fis1 and Mff participate in cardiomyocyte apoptosis induced by hypoxia or H2O2. The gene discussed is FIS1; the disease is heart disorder.