ERBB4 and heart disorder: Aberrant expression of miRNAs in the heart is related to heart disease.42, 43 It has been shown that upregulation of miR-146a after DOX treatment is involved in DOX cardiotoxicity by targeting ErbB4.44 Upregulation of miR-1 and miR-133 contributes to arsenic-induced cardiac electrical disorders.45 Only a few miRNAs have been found to be involved in cardiotoxicity.