LEP and obesity due to melanocortin 4 receptor deficiency: Therefore, in the present study, we used whole genome transcriptome profiling of PBMCs of pups from calorie-restricted dams during gestation in order to identify early biomarkers of programmed susceptibility to obesity-related chronic diseases and to determine whether supplementation with physiological doses of leptin during the suckling period is able to revert these markers of developmental malprogramming.