This prenatal condition exerts adverse health effects on the offspring, leading to hyperphagia, hypertension and greater fat accumulation16, 18, impaired insulin and leptin sensitivity15, alterations in the structure and expression of neuropeptides regulating feeding behaviour in hypothalamus28, 29 as well as alterations in adipose tissue and stomach sympathetic innervations44, 45. The gene discussed is INS; the disease is hypertensive disorder.