The following DNA repair pathways were implicated: BER (e.g. APLF, MBD4, NEIL3 and NEIL2), NER (e.g. RPA2, UVSSA, XPA, GTF2H1, XPE and DDB1), HR (e.g. RAD50, NBN, XRCC3, RAD51 and DMC1), nonhomologous end-joining (NHEJ), modulation of nucleotide pools, DNA polymerases, editing and processing nucleases, ubiquitination and modification, genes defective in diseases associated with sensitivity to DNA damaging agents, and Fanconi anemia (Supplementary Figure S8). This evidence concerns the gene APLF and Fanconi anemia.