SPIB is amplified in Activated B Cell Diffuse Large B Cell Lymphomas (ABC-DLBCL) compared with other B cell lymphoma subtypes, and is translocated in the OCI-Ly3 ABC-DLBCL cell line leading to over-expression of SPIB mRNA compared with other lines [20,21]. This evidence concerns the gene SPIB and diffuse large B-cell lymphoma.