Along these lines, we note that Saferali and colleagues recently reported a single-nucleotide polymorphism (SNP; rs1078761) that is associated with a decreased abundance of SPLUNC1 protein, and worsened lung function, in the airways of individuals with cystic fibrosis (Saferali et al., 2015). The gene discussed is BPIFA1; the disease is cystic fibrosis.