BPIFA1 and lung disorder: Although Splunc1-deficient mice do not develop spontaneous lung disease in the absence of a bacterial insult, they do exhibit impaired responses to intrapulmonary challenge with Mycoplasma pneumoniae (Gally et al., 2011), Pseudomonas aeruginosa (Liu et al., 2013a) and Klebsiella pneumoniae (Liu et al., 2013b), and overexpression of Splunc1 protects mice from inhaled P. aeruginosa (Lukinskiene et al., 2011).