The participant is a carrier of homozygous genotypes at three of the following deleterious SNPs; rs2304256 [19:g.10475652C > A] [Val362Phe] (TYK2 gene [MIM:*176941]), rs1799990 [20:g.4680251A > G] [Met129Val] (PRNP gene [MIM:*176640]), rs676210 [2:g.21231524G > A] [Pro2739Leu] (APOB gene [MIM:+107730] – these markers are associated with susceptibility to Type 1 diabetes [30], long-term memory [31] and triglycerides level [32-34], The observed homozygous genotype of (AA) at rs2304256 provides protection from Type 1 diabetes [30]. Here, TYK2 is linked to type 1 diabetes mellitus.