Genes were divided into three clusters (i) 36 genes which have lower gene expression values in both AD-iPS neuron compared to H9 neurons, among them PSMC1, PSMA5, NEDD8. (ii) 2 genes characterized by higher expression in both AD-iPS neuron compared to H9 neurons: PSMD5, PSMB9. (iii) 25 genes the expression of which varies between the three samples. The gene discussed is NEDD8; the disease is Alzheimer disease.