The expression of the largest set of genes was allocated to pons with 12% in the case of AD-iPS5 neurons for the genes APOE, APP, ATP2A2, CALM2, CALM3, CAPN2, CDK5, GAPDH, GSK3B and PPP3CB (Figure 4c) and 13% in AD-iPS26B neurons for the genes APP, ATP2A2, CALM2, CALM3, CDK5, GAPDH and GSK3B (Figure 4d). The gene discussed is APOE; the disease is Alzheimer disease.