Our findings showing Th2 priming by C. neoformans, combined with work by Schlitzer et al. showing IRF4-dependent DC are capable of priming Th17 cells in response to A. fumigatus to pulmonary fungal infection, highlight a fatal flaw in the notion that DC subsets are inherently specialized to control Th cell lineage fate. Here, IRF4 is linked to fungal lung infectious disease.