Evaluation of markers of endothelial activation showed that ICAM-1 levels were positively associated with BH2 (r = 0.4, p = 0.02) and inversely associated with BH4 (r = -0.38, p = 0.04) and the BH4/BH2 ratio (r = -0.52, p = 0.003) in all malaria patients, but only with BH4/BH2 (r = -0.63, p = 0.03) in the SM group. Here, ICAM1 is linked to malaria.