Fig. 5D shows a comparison of the expression profiles of protein index between JHU-22miR-128 and JHU-22vect tumor xenografts. Again, the levels of BMI-1 (30/80), PNCA (21/30) and cyclin D1 (37/65) were significantly down-regulated in the JHU-22miR-128 group compared with the control JHU-22vect group. The gene discussed is BMI1; the disease is neoplasm.