The protein level of BAG-2 was extremely high in the HNSCC JHU-22 cells (Fig. 2A), however, up-expressed miR-128 in the JHU-22miR-128 cells was able to attenuate BAG-2 protein significantly, even though BAG-2 had a relative lower binding capacity with miR-128 compared to BMI-1, H3F3B, or BAX (Table 1). Here, BMI1 is linked to head and neck squamous cell carcinoma.