The analysis of regulatory pathway of these target genes indicated a significant enrichment in several pathways related to neuronal brain function of the depression such as PI3K-Akt signaling pathway, Axon guidance, Wnt signaling pathway, Neurotrophin signaling pathway, Hippo signaling pathway, mTOR signaling pathway, ErbB signaling pathway, Cell cycle, Apoptosis, Long-term depression(data no shown). This evidence concerns the gene EGFR and major depressive disorder.